| 產(chǎn)品編號(hào) | bs-24090R-BF488 |
| 英文名稱1 | Rabbit Anti-HJURP/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的HJURP蛋白抗體 |
| 別 名 | 14-3-3-associated AKT substrate; FAKTS; fetal liver expressing gene 1; Fetal liver-expressing gene 1 protein; FLEG1; hFLEG1; HJURP; Holliday junction recognition protein; Up-regulated in lung cancer 9; URLC9. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 84kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse HJURP |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: HJURP is a 748 amino acid protein that is expressed in thymus, placenta, small intestine, liver, skeletal muscle, bone marrow and colon. When histone H3-like variant CENP-A nucleosomes are assembled, HJURP localizes in centromeres during late telophase and early G1 phase, and localizes to the nucleolus during S phase. Considered a centromeric protein, HJURP plays a central role in the incorporation and maintenance of CENP-A at centromeres. HJURP also acts as a specific chaperone for CENP-A and is required for the incorporation of newly synthesized CENP-A molecules into nucleosomes at replicated centromeres. HJURP is considered an indispensable factor for chromosomal stability in immortalized cancer cells and is a potential novel therapeutic target for the development of anticancer drugs. Function: Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Directly binds Holliday junctions. Subcellular Location: Nucleus; nucleolus. Centromere. Note: Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage. Database links:
Entrez Gene: 55355 Human
Entrez Gene: 381280 Mouse
Omim: 612667 Human
SwissProt: Q8NCD3 Human
SwissProt: Q6PG16 Mouse
Unigene: 532968 Human
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
