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Rabbit Anti-ACTHR, BF680 conjugated antibody (bs-11408R-BF680)  
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說明書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11408R-BF680
英文名稱 Rabbit Anti-ACTHR, BF680 conjugated antibody
中文名稱 BF680標記的促腎上腺皮質激素受體
別    名 ACTH receptor; ACTH-R; ACTHR; ACTHR_HUMAN; Adrenocorticotropic hormone receptor; Adrenocorticotropin receptor; Corticotropin receptor; MC2 receptor; MC2-R; MC2R; Melanocortin 2 receptor (adrenocorticotropic hormone); Melanocortin 2 receptor; Melanocortin receptor 2.  
研究領域 腫瘤  心血管  細胞生物  神經生物學  信號轉導  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 34kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MC2 receptor: 67-105/297 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency.

Function:
Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.

Subunit:
Interacts with FALP/MRAP.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Melanocytes and corticoadrenal tissue.

DISEASE:
Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
Q92506

Gene ID:
4158

Database links:

Entrez Gene: 483980 Dog

Entrez Gene: 4158 Human

Entrez Gene: 17200 Mouse

Entrez Gene: 282839 Rat

Omim: 607397 Human

SwissProt: Q01718 Human

SwissProt: Q64326 Mouse

Unigene: 248144 Human

Unigene: 426053 Mouse

Unigene: 92460 Rat



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